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Abstract

Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a boneforming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; also provided are antibodies directed against black bear parathyroid hormone (PTH) and functional fragments thereof.

Patent Number

7994129

Assignee

Michigan Technological University, Houghton, MI (US)

Application Number

11/559,285

Date Filed

11-13-2006

Certificate of Correction

Yes

Issue Date

8-9-2011

Disciplines

Biological Engineering | Engineering

Methods of using black bear parathyroid hormone

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