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Abstract

This invention provides a method for purifying synthetic oligonucleotides comprising capping, polymerizing and separating any failure sequences produced during oligonucleotide synthesis. The invention also provides a method for purifying synthetic oligonucleotides comprising reacting a full length oligonucleotide with a compound to attach a polymerizable functional group to an end of the full length oligonucleotide, polymerizing the full length oligonucleotides and removing the failure sequences, and recovering the full length oligonucleotides. The invention also provides novel capping agents having a polymerizable functional group, and kits comprising at least one composition of the present invention.

Patent Number

9,243,023

Assignee

Michigan Technological University, Houghton, MI (US)

Application Number

13/876,201

Date Filed

9-27-2011

Certificate of Correction

No

Issue Date

1-26-2016

Disciplines

Polymer Chemistry

Purification of synthetic oligonucleotides

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