Title

Synthesis of 3-Amino-2,2-dimethyl-8-thia-1-azaspiro[4.5]decane

Document Type

Article

Publication Date

8-5-2010

Abstract

The synthesis of 3-amino-2,2-dimethyl-8-thia-1-azaspiro[4.5]decane is described. Key steps include the addition of prenyl magnesium bromide to a 4-methoxybenzylimine without reversal of stereochemistry and the iodine-initiated aminocyclization to form the azaspirocycle.

Publisher's Statement

Publisher's version of record: http://dx.doi.org/10.1080/00397910903289255

Publication Title

Synthetic Communications