Date of Award

2016

Document Type

Campus Access Master's Thesis

Degree Name

Master of Science in Chemistry (MS)

Administrative Home Department

Department of Chemistry

Advisor 1

Haiying Liu

Committee Member 1

Tarum K. Dam

Committee Member 2

Xiaohu Xia

Abstract

Fluorescent probes have become a powerful tool for scientists to selectively detect a wide variety of substances in living cells due to their simplicity and high sensitivity, enabling scientists to monitor them and to understand their physiological and pathological processes. A constant lysosomal pH is a prerequisite for more than 70 kinds of hydrolytic enzymes in lysosomes from all eukaryotic cells to function well, while zinc (II) ions play a vital role in numerous cellular metabolism. Abnormal lysosomal pH and Zn (II) ions concentration in cells always associate with many serious diseases. However, the emission and excitation peak of the most fluorescent probes are in the visible range which cause some issues, such as photo damage to cells and high fluorescence background. Therefore, novel near-infrared fluorescent probes for selectively detecting lysosomal pH and Zn (II) ions, respectively, with good aqueous solubility were developed to overcome these limitations.

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