Title

Synthetic oligodeoxynucleotide purification by polymerization of failure sequences

Document Type

Article

Publication Date

11-17-2010

Abstract

Synthetic oligodeoxynucleotide is purified by capping failure sequences with an acrylated phosphoramiditefollowed by polymerization and product extraction. The method is suitable for large scale oligonucleotide drugpurification.

Publisher's Statement

© Royal Society of Chemistry. Publisher's version of record: http://dx.doi.org/10.1039/C0CC04374E

Publication Title

Chemical Communications