In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel
We present a simple microfluidic technique to in-situ photopolymerize (by 365 nm ultraviolet) monodisperse oxidized methacrylated alginate (OMA) microgels using a photoinitiator (VA-086). By this technique, we generated monodisperse spherical OMA beads and discoid non-spherical beads with better shape consistency than ionic crosslinking methods do. We found that a high monomer concentration (8 w/v %), a high photoinitiator concentration (1.5 w/v %), and absence of oxygen are critical factors to cure OMA microgels. This photopolymerizing method is an alternative to current methods to form alginate microgels and is a simpler approach to generate non-spherical alginate microgels.
Wang, Shuo; Jeon, Oju; Shankles, Peter G.; Liu, Yuan; Alsberg, Eben; Retterer, Scott T.; Lee, Bruce P.; and Choi, Chang Kyoung, "In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel" (2016). Department of Biomedical Engineering Publications. 7.