A moldable nanocomposite hydrogel composed of a Mussel‐inspired polymer and a nanosilicate as a fit‐to‐shape tissue sealant
The engineering of bioadhesives to bind and conform to the complex contour of tissue surfaces remains a challenge. We have developed a novel moldable nanocomposite hydrogel by combining dopamine-modified poly(ethylene glycol) and the nanosilicate Laponite, without the use of cytotoxic oxidants. The hydrogel transitioned from a reversibly cross-linked network formed by dopamine–Laponite interfacial interactions to a covalently cross-linked network through the slow autoxidation and cross-linking of catechol moieties. Initially, the hydrogel could be remolded to different shapes, could recover from large strain deformation, and could be injected through a syringe to adhere to the convex contour of a tissue surface. With time, the hydrogel solidified to adopt the new shape and sealed defects on the tissue. This fit-to-shape sealant has potential in sealing tissues with non-flat geometries, such as a sutured anastomosis.
Angewandte Chemie International Edition
Lin, Yuan; Meng, Hao; Qian, Zichen; Fan, Ni; Choi, Wonyoung; Zhao, Feng; and Lee, Bruce P., "A moldable nanocomposite hydrogel composed of a Mussel‐inspired polymer and a nanosilicate as a fit‐to‐shape tissue sealant" (2017). Department of Biomedical Engineering Publications. 30.